Literature Review : In Vitro And In Vivo Study Of Anti-Cancer Activity Of Syzygium Cumini Fruit, Stem Bark, Seeds, Leaves
Abstract
Indonesia is a country that has very abundant natural
resources (Summa, 2019), one of which is by having
various types of plants that have properties for
traditional medicine (Adiyasa & Meiyanti, 2021). For
this reason, Indonesian people are very interested in
traditional medicines because the plant-based
ingredients are easy to get, easy to mix, and also very
affordable prices (Widaryanto & Azizah, 2018).
Jamblang fruit (Syzygium cumini L.) is one of the
tropical fruits that can be used as medicine to treat
various diseases. Jamblang fruit can be found in
Australia, Tropical Asia, and Indonesia. Jamblang or
duwet fruit is a plant that belongs to the Myrthacceae
family, all parts starting from fruit, leaves, seeds of
jamblang fruit can be used as traditional medicine
(Katiyar et al., 2016). The jamblang fruit itself has
several ingredients in it, including high levels of
flavonoids, alkaloids, resins, tannins, and also essential
oils so that the jamblang fruit is very beneficial for
health. The jamblang seeds contain gallic acid, ellagic
acid, corilagen, 3,6-hexahydroxy diphenoylglucose, 1-
galloylyglucose, 3galloylyglucose, quercetin, β-
sitostero, quercetin kaempferol, myricetin, and genin (Jagetia, 2017). Whereas jamblang leaves themselves
contain acylated flavonol glycosides, triterpenoids,
tannins, quercetin, myricetin, myricitin, myricetin 3-O-
4-acetyl-Lrhamnopyranoside, esterase, and galloyl
carboxylase (Kumawat et al., 2018). For this reason,
the compounds contained in jamun fruit make
jamblang fruit a plant that has properties as
antidiabetic, anti-inflammatory, anticancer,
antioxidant, hypoallergenic, antiviral, antifungal,
antibacterial, and also antipyretic (LPPM Biopharma
Study Center, IPB & Gagas Ulung, 2014)
References
Abbas, M. W., Hussain, M., Akhtar, S., Ismail, T., Qamar, M., Shafiq, Z., & Esatbeyoglu, T. (2022). Bioactive Compounds, Antioxidant, Anti-Inflammatory, Anti-Cancer, And Toxicity Assessment Of Tribulus Terrestris—In Vitro And In Vivo Studies. Antioxidants, 11(6), 1160.
Abd Gafur, M., Isa, I., & Bialangi, N. (2011). Isolasi Dan Identifikasi Senyawa Flavonoid Dari Daun Jamblang (Syzygium Cumini). Jurusan Kimia Fakultas MIPA Universitas Negeri Gorontalo, 2.
Abriyani, E., Nurheni, A., Adam, A. N. Z., Sinangling, B. A., Fatwa, D. N., & Ulwani, M. A. (2023). Aktivitas Tumbuhan Jamblang (Syzygium Cumini L.) Secara Metode Spektrofotometri Uv-Visible: Literature Review Article. Comserva: Jurnal Penelitian Dan Pengabdian Masyarakat, 2(09), 1588-1592.
Al-Hamda, H. M., Swasti, E., & Satria, B. (2022). Fertilitas Dan Viabilitas Polen Tanaman Jamblang (Syzygium Cumini (L.) Skeels) Asal Sumatera Barat. Jurnal Pertanian Agros, 24(2), 487-496.
Artanti, N., Maryani, F., Dewi, R. T., Handayani, S., Dewijanti, I. D., Meilawati, L., ... & Udin, L. Z. (2019). In Vitro Antidiabetic, Antioxidant And Cytotoxic Activities Of Syzygium Cumini Fractions From Leaves Ethanol Extract. Indonesian Journal Of Cancer Chemoprevention, 10(1), 24-29.
Chhikara, N., Kaur, R., Jaglan, S., Sharma, P., Gat, Y., & Panghal, A. (2018). Bioactive Compounds And Pharmacological And Food Applications Of Syzygium Cumini–A Review. Food & Function, 9(12), 6096-6115.
Dewi, S. R. (2018). Uji Efek Anti Inflamasi Rebusan Daun Jamblang (Syzygium Cumini) Pada Mencit (Mus Musculus). Media Farmasi, 14(1), 8-13.
Handayani, P. N. (2015). Isolasi, Seleksi, Dan Uji Aktivitas Antimikroba Kapang Endofit Dari Daun Tanaman Jamblang (Syzygium Cumini L.) Terhadap Escherichia Coli, Pseudomonas Aeruginosa, Bacillus Subtilis, Staphylococcus Aureus, Candida Albicans Dan Aspergillus Niger.
Hidayah, H., Amal, S., Sundara, A. K., & Nurfadilah, D. (2022). Pengembangan Sediaan Kosmetik Dari Bahan Alam Formulasi Serum Dan Facial Wash Dari Daun Jamblang (Syzygium Cumini (L) Skeels)
Hidayah, H., Gunarti, N. S., Oktaviani, S. P., & Amal, S. (2023). Potensi Tumbuhan Jamblang (Syzygium Cumini (L.) Skeels) Sebagai Hepatoprotektor Berdasarkan Kandungan Senyawa Aktif: Literature Review Article. Jurnal Buana Farma, 3(1), 1-7.
Hidayah, H., Ridwanuloh, D., & Amal, S. (2021). Aktivitas Farmakologi Tumbuhan Jamblang (Syzygium Cumini L.): Literature Review Article. Cerdika: Jurnal Ilmiah Indonesia, 1(5), 530-536.
Katiyar, D., Singh, V., & Ali, M. (2016). Recent Advances In Pharmacological Potential Of Syzygium Cumini: A Review. Advances In Applied Science Research, 7(3), 1-12.
Kumar, S., & Singh, B. (2021). Syzygium Cumini (Jamun) Its Medicinal Uses. Int. J. Pharmacogn, 8, 361-372.
Maliza, N. O., Safrida, S., Hayuningtyas, A., & Ayunda, H. M. (2022). Literatur Review: Potensi Pengolahan Dan Manfaat Kesehatan Jamblang (Syzygium Cumini L.). Jurnal Teknologi Pengolahan Pertanian, 4(2), 72-80.
Masruroh, I. N. (2016). Uji Aktivitas Antihiperurisemia Ekstrak Metanol Biji Juwet (Syzygium Cumini (L.) Skeels) Pada Mencit Jantan Galur Balb-C Hiperurisemia.
Mittal, A. K., Bhaumik, J., Kumar, S., & Banerjee, U. C. (2014). Biosynthesis Of Silver Nanoparticles: Elucidation Of Prospective Mechanism And Therapeutic Potential. Journal Of Colloid And Interface Science, 415, 39-47.
Pratiwi, R., & Nurlaeni, Y. (2020). Screening Of Plant Collection Of Cibodas Botanic Gardens, Indonesia With Anticancer Properties. Biodiversitas Journal Of Biological Diversity, 21(11).
Putriana, A., Pondini, D. A., Pitaloka, L., & Hidayah, H. (2023). Jamblang (Syzygium Cumini (L.)): A Review Of It’s Fruit And Medicinal Uses. Innovative: Journal Of Social Science Research, 3(2), 7536-7543.
Qamar, M., Akhtar, S., Ismail, T., Wahid, M., Abbas, M. W., Mubarak, M. S., ... & Esatbeyoglu, T. (2022). Phytochemical Profile, Biological Properties, And Food Applications Of The Medicinal Plant Syzygium Cumini. Foods, 11(3), 378.
Renggana, H., Hadisaputri, Y. E., & Subarnas, A. (2019). Aktivitas Antikanker Famili Myrtaceae. Jurnal Ilmiah Farmako Bahari, 9(2), 23-32.
Sari, A. N., Kusdianti, K., & Diningrat, D. S. (2018). Analisis GC-MS Senyawa Bioaktif Pencegah Penyakit Degeneratif Dari Ekstrak Etanol Kulit Buah Jamblang (Syzygium Cumini). Elkawnie: Journal Of Islamic Science And Technology, 4(2), 101-114.
Sharma, R., Oberoi, K., Sharma, K., Nagraik, R., Kumar, D., Sharma, A., & Sharma, S. (2020). Bioactive Compounds And Ethnomedicinal Uses Of Syzygium Cumini (L.) Skeels-A Comprehensive Review. The Annals Of The University Dunarea De Jos Of Galati. Fascicle VI-Food Technology, 44(1), 230-254.
Siagian, D. G., & Roza, D. (2021). Studi Molecular Docking Senyawa Antosianidin Dari Ekstrak Buah Jamblang (Syzygium Cumini) Sebagai Senyawa Anti-Tumor Secara In Silico.
Siddika, A., Das, P. K., Asha, S. Y., Aktar, S., Tareq, A. R., Rakib, A., ... & Khanam, J. A. (2021). Antiproliferative Activity And Apoptotic Efficiency Of Syzygium Cumini Bark Methanolic Extract Against EAC Cells In Vivo. Anti-Cancer Agents In Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 21(6), 782-792.
Silalahi, M. (2018). Jamblang (Syzygium Cumini (L.) Dan Bioaktivitasnya. Jurnal Terpadu Ilmu Kesehatan, 7(2), 124-132.
Sutrisna, I. G. P. A. F., Juliantara, I. K. P., & Sita, A. S. R. (2018). Perbandingan Antibakteri Ekstrak Dari Daun, Kulit Batang Dan Buah Juwet (Syzygium Cumini) Terhadap Pertumbuhan Bakteri Salmonella Typhi. Bali Health Journal, 2(2), 95-102.
Tafrihani, A. S., Gono, C. M. P., Natasia, N., & Ikawati, M. (2021). Potensi Biji Duwet (Syzygium Cumini (L.)(Skeels.)) Sebagai Imunomodulator Pendamping Kemoterapi: Sebuah Ulasan. J Pharm Sci, 2, 217.
TRI, W. (2022). Fortifikasi Yogurt Ekstrak Daun Binahong (Anredera Cordifolia (Ten). Steenis) Sebagai Kandidat Terapi Kolitis Ulseratif Pada Mencit Yang Di Induksi Asam Asetat 3% (Doctoral Dissertation, Universitas Al-Irsyad Cilacap).
Widyastuti, W., & Hilaliyati, N. (2021). Potensi Ekstrak Buah Jambu Jamblang (Syzygium Cumini L. Skeel) Sebagai Antioksidan Dan Tabir Surya. Jurnal Ilmiah Farmasi Farmasyifa, 4(1), 112-119.
Zaen, D. M., & Ekayanti, M. (2022). Penetapan Flavonoid Total Dan Uji Aktivitas Antioksidan Ekstrak Etanol Dari Daun Jambu Air (Syzygium Aqueum), Daun Jambu Bol (Syzygium Malaccense) Dan Daun Jamblang (Syzygium Cumini). Jurnal Kedokteran Universitas Palangka Raya, 10(2), 15-18. Mittal, A. K., Bhaumik, J., Kumar, S., & Banerjee, U. C. (2014). Biosynthesis Of Silver Nanoparticles: Elucidation Of Prospective Mechanism And Therapeutic Potential. Journal Of Colloid And Interface Science, 415, 39-47.
